Many types of tumour, either directly or indirectly, compromise the ability of the kidney to eliminate a calcium load derived from increased bone destruction. The general availability of an ever-expanding range of increasingly potent bisphosphonates has resulted in a dramatic improvement in the treatment of increased bone resorption associated with malignancy. Disassembly of the prosthetic knee components. Misalignment of the prosthetic knee components. Dislocation and/or joint instability of the prosthetic knee.
These include: Loosening or fracture of the prosthetic knee components. These two components of hypercalcaemia demand different approaches to management. With any knee replacement, there is the risk of adverse events. Hypercalcaemia of malignancy is usually the result of both increased bone destruction and decreased urinary calcium excretion. There is now potential for long term control of bone turnover with the hope of preventing late complications. The increasing potency and safety margin of the newer agents has meant that the threshold for treatment has fallen. The condition is a result of a primary increase in osteoclastic bone resorption which can be corrected by bisphosphonates, with considerable symptomatic improvement. The management of Paget's disease has been quite revolutionised by the introduction of the bisphosphonates. According to this paper, collagen denatures at temperatures around 220 degrees Celsius in a dehydrated environment after gradual heating at transitional temperature intervals. Replacing lost bone may not necessarily restore mechanical integrity and protect against fractures. The mechanical properties of bone (like Elastic modulus) are generally dependent on a protein called collagen and its cross links. The great problem of treating the established condition is that substantial bone loss is accompanied by architectural disintegration. The attraction of preventing bone loss is that it preserves the micro-architecture of bone, and therefore its mechanical integrity. The role of bisphosphonates in achieving the same result is being actively explored. The condition can be prevented by the early introduction of hormone replacement therapy. Osteoporosis is the most important metabolic bone disease and places an increasing burden on the healthcare system.